Aptamer

I've drafted an initial article on Aptamer. Please review.

Review by Critic Carla:

The article is well-written, technically accurate, and correctly focuses on the topic of Aptamers. The tone is appropriately neutral and encyclopedic.

• Expand the "Comparison with Antibodies" section: The current table is rendered in Markdown/Wiki-text format within the HTML body, which may not display correctly as a formatted table in all viewers. Ensure this is converted to a proper HTML `` to match the infobox style.
• Add a "Natural Aptamers" subsection: While the lead mentions riboswitches, the article focuses almost exclusively on synthetic aptamers. Adding a dedicated subsection on naturally occurring aptamers (like those found in bacterial mRNA) would provide a more comprehensive biological context.
• Clarify "Notable Contributors": The infobox lists "Developers of the SELEX process" generically. This should be updated to name the specific scientists (e.g., Andrew Ellington and Peter Winter) to provide the academic precision expected of an encyclopedia.
• Enhance the "Future Directions" section with specific examples: While the mention of NGS and multivalent aptamers is good, the section would benefit from mentioning "slow off-rate modified aptamers" (SOMAmers) or other specific emerging chemical modifications that are currently shaping the field.

Fact-check by Fact-Checker Finn:

• Factual Error (Size): In the comparison table, the size of aptamers is listed as $\sim 10\text{--}30 \text{ kDa}$. This is significantly overestimated; most aptamers are short oligonucleotides (typically 20–60 nucleotides) with molecular weights usually ranging from $6\text{--}20 \text{ kDa}$.
• Absolute Language: The claim that chemical synthesis "eliminates the risk of immunogenicity" is too absolute. While aptamers are generally non-immunogenic, certain chemical modifications or the delivery vehicles they are attached to can still trigger immune responses.
• Missing Nuance: The article states that aptamers are "highly stable" in the comparison table, but later contradicts this by noting their "susceptibility to nucleases in the bloodstream." The table should specify that stability refers to thermal stability (reversible folding) rather than metabolic stability.
• Vague Attribution: The "Notable contributors" section of the infobox lists "Developers of the SELEX process" rather than naming the specific individuals (e.g., Ellington and Winter) mentioned in the references.

Review complete. Some issues were flagged. @Scientist Sage, please address the feedback.